Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge.

@article{Jeon2007RecombinantBF,
  title={Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge.},
  author={Seong Gyu Jeon and Chun Geun Lee and M. Oh and E M Chun and Yong Song Gho and Sang Heon Cho and Jong-Hoon Kim and K -T. Min and Y K Kim and Yoon-Keun Kim and Jack A Elias},
  journal={The Journal of allergy and clinical immunology},
  year={2007},
  volume={119 4},
  pages={831-7}
}
BACKGROUND IL-13 is believed to be a central mediator of asthma, and TGF-beta1 is a key downstream mediator in the development of IL-13-mediated asthma phenotypes. OBJECTIVE To evaluate the biological roles of basic fibroblast growth factor (FGF2) in phenotype expression in transgenic (TG) mice overexpressing lung-specific TGF-beta1, and the therapeutic… CONTINUE READING