Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells.

@article{Zhong1999RecombinantAI,
  title={Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells.},
  author={Le Zhong and Angela Granelli-Piperno and Young-Eun Choi and Ralph Marvin Steinman},
  journal={European journal of immunology},
  year={1999},
  volume={29 3},
  pages={964-72}
}
Recombinant adenoviral vectors have promise for human gene therapy because of efficient transgene expression in nondividing primary cell types. Dendritic cells (DC) have potential as adjuvants for immune therapy, since they are specialized to capture antigens to form MHC-peptide complexes, migrate to T cell areas in the lymph node, and activate T cells including CD4+ helpers and CD8+ cytotoxic T lymphocytes (CTL). We show that several current chemical and physical transfection methods allow < 2… CONTINUE READING

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