Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice.

@article{Zeng2011RecombinantAC,
  title={Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice.},
  author={Xin Zeng and Yong Lin and C. G. Yin and Xin Zhang and Bei-fang Ning and Qing Zhang and Junping Zhang and Lei Qiu and Xiao-ran Qin and Yue-xiang Chen and Wei Fen Xie},
  journal={Hepatology},
  year={2011},
  volume={54 6},
  pages={2036-47}
}
UNLABELLED Hepatocyte nuclear factor-1alpha (HNF1α) is one of the key transcription factors of the HNF family, which plays a critical role in hepatocyte differentiation. Substantial evidence has suggested that down-regulation of HNF1α may contribute to the development of hepatocellular carcinoma (HCC). Herein, human cancer cells and tumor-associated fibroblasts (TAFs) were isolated from human HCC tissues, respectively. A recombinant adenovirus carrying the HNF1α gene (AdHNF1α) was constructed… CONTINUE READING
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