Recombinant adeno-associated virus vectors for gene therapy.

@article{Conlon2004RecombinantAV,
  title={Recombinant adeno-associated virus vectors for gene therapy.},
  author={Thomas J. Conlon and Terence R. Flotte},
  journal={Expert opinion on biological therapy},
  year={2004},
  volume={4 7},
  pages={1093-101}
}
Recombinant adeno-associated virus (rAAV) vectors are based on a non-pathogenic human parvovirus (AAV) that is unique in its ability to persist in human cells without causing any pathologic effects. Studies of the potential barriers to rAAV-mediated transduction of relatively resistant cells has led to an understanding of the mechanisms of cell attachment and entry, cytoplasmic translocation, nuclear entry, conversion to active double-stranded DNA, activation of transcription and establishment… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…