Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion.

@article{Mastakov2002RecombinantAV,
  title={Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion.},
  author={Mihail Y. Mastakov and Kristin Baer and Robert M. Kotin and Matthew John During},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2002},
  volume={5 4},
  pages={371-80}
}
Recombinant adeno-associated viruses (rAAVs) are among the most promising vectors for gene delivery into the CNS. However, a major hurdle for gene transfer to the mammalian brain is to achieve high transduction levels in target cells beyond the immediate injection site. Therefore, building upon the optimization of injection parameters on which we have… CONTINUE READING