Recombinant adeno-associated virus (AAV) drives constitutive production of glutamate decarboxylase in neural cell lines.

@article{Mi1999RecombinantAV,
  title={Recombinant adeno-associated virus (AAV) drives constitutive production of glutamate decarboxylase in neural cell lines.},
  author={Jingwen Mi and Saswati Chatterjee and Kenny K. Wong and Chas. Forbes and Gary Lawless and Allan J. Tobin},
  journal={Journal of neuroscience research},
  year={1999},
  volume={57 1},
  pages={
          137-48
        }
}
Many neurological disorders result directly or indirectly from the loss of inhibitory function. Engineering the production of GABA, an inhibitory neurotransmitter, may therefore be able at least partly to restore the lost inhibition seen in epilepsy, Parkinson's disease, or Huntington's disease. In this article, we describe a set of recombinant adeno-associated viruses (AAVs) that can deliver cDNAs encoding the GABA-producing enzyme, glutamate decarboxylase (GAD), directly into neural cells. We… CONTINUE READING