Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke.

@article{Bouchama2008RecombinantAP,
  title={Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke.},
  author={Abderrezak Bouchama and Corinne Kunzelmann and Mohammed Dehbi and Aaron A. Kwaasi and Abdelmoneim M. Eldali and Fatiha Zobairi and J. -M. Freyssinet and Dominique de Prost},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 7},
  pages={1318-25}
}
OBJECTIVE We tested the hypothesis that the antithrombotic and cytoprotective effects of recombinant human activated protein C (rhAPC) protect baboons against the lethal effects of heatstroke. METHODS AND RESULTS Fourteen anesthetized baboons assigned randomly to rhAPC (n=7) or control group (n=7) were heat-stressed in a prewarmed incubator at 44 to 47 degrees C until systolic blood pressure fell below 90 mm Hg, which signaled severe heatstroke. rhAPC was administered intravenously (24 microg… CONTINUE READING