Recombinant activated factor VII in cardiac surgery: a meta-analysis.

@article{Zangrillo2009RecombinantAF,
  title={Recombinant activated factor VII in cardiac surgery: a meta-analysis.},
  author={Alberto Zangrillo and Aur{\'e}lie Mizzi and Giuseppe Biondi-Zoccai and Elena Bignami and Maria Grazia Calabr{\`o} and Federico Pappalardo and Elisa Dedola and Luigi Tritapepe and Giovanni P Marino and Giovanni Landoni},
  journal={Journal of cardiothoracic and vascular anesthesia},
  year={2009},
  volume={23 1},
  pages={
          34-40
        }
}
OBJECTIVE Perioperative microvascular bleeding is associated with increased morbidity and mortality and could be reduced by hemostatic drugs such as recombinant activated factor VII (rFVIIa). Few trials have investigated rFVIIa and each individually lacked power to detect a beneficial effect on transfusion of blood products or thromboembolic side effects. DESIGN Meta-analysis. SETTING Hospitals. PARTICIPANTS The authors performed a meta-analysis of 5 clinical trials (1 randomized, 3… CONTINUE READING
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