Recombinant West Nile virus envelope protein E and domain III expressed in insect larvae protects mice against West Nile disease.

Abstract

In this study, West Nile virus (WNV) envelope (rE) protein and its domain III (rDIII) were efficiently expressed in a cost-effective system based on insect larvae as non-fermentative living biofactories. Mice immunized with the partially purified rE or rDIII elicited high antibodies titers that neutralized viral infectivity in cell culture and in suckling… (More)
DOI: 10.1016/j.vaccine.2010.12.081

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