Recombinant Thrombin: Safety and Immunogenicity in Burn Wound Excision and Grafting

@article{Greenhalgh2009RecombinantTS,
  title={Recombinant Thrombin: Safety and Immunogenicity in Burn Wound Excision and Grafting},
  author={David G. Greenhalgh and Richard L. Gamelli and Jay N. Collins and Rajiv Sood and David W. Mozingo and T. E. Gray and W. Allan Alexander},
  journal={Journal of Burn Care \& Research},
  year={2009},
  volume={30},
  pages={371-379}
}
This study evaluated the safety, immunogenicity, and hemostatic effect of recombinant human Thrombin (rThrombin), in patients undergoing skin grafting for burns. This was a phase 2 multiple site, single-arm, open-label study in patients receiving partial- or full-thickness autologous grafts. rThrombin was applied using a spray applicator to newly excised wounds of 1 to 4% body surface area at 5 minutes intervals for up to 20 minutes, after point source bleeding was stopped. Adverse events, skin… 

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