Recombinant Shiga toxin B subunit can induce neutralizing immunoglobulin Y antibody.

@article{Neri2012RecombinantST,
  title={Recombinant Shiga toxin B subunit can induce neutralizing immunoglobulin Y antibody.},
  author={Paola Neri and Shunji Tokoro and Tsuyoshi Sugiyama and Kouji Umeda and Takeshi Shimizu and Tsutomu Tsuji and Yoshikatsu Gifu-shi Kodama and Hiroshi Mori},
  journal={Biological & pharmaceutical bulletin},
  year={2012},
  volume={35 6},
  pages={
          917-23
        }
}
Previously, we have shown that chickens immunized with Shiga toxin (Stx) produce Stx-neutralizing egg yolk immunoglobulin Y (IgY) antibody. The anti-Stx-1 IgY and anti-Stx-2 IgY exert their neutralizing activity through their antibody activity against the B subunit of the toxin but not the A subunit. In the present study, chickens were immunized with recombinant Stx-1 B subunit (rStx-1B) and recombinant Stx-2 B subunit (rStx-2B). Induced anti-rStx-1B and anti-rStx-2B IgY neutralized the… CONTINUE READING

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