Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies

@article{Smith1994RecombinantPI,
  title={Recombinant Polymeric IgG: An Approach to Engineering More Potent Antibodies},
  author={R. Smith and S. Morrison},
  journal={Bio/Technology},
  year={1994},
  volume={12},
  pages={683-688}
}
IgM and IgG are the only classes of immunoglobulin capable of initiating the classical complement cascade. IgM, however, fixes complement much more effectively than IgG making it a more attractive Fc for some immunotherapeutic strategies. IgG, on the other hand, triggers additional effector functions mediated through γ specific Fc receptors. Using a generalizable technique we have produced IgM-like polymers of IgG that possess both the Fcγ receptor binding properties of IgG and the more potent… Expand
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