Recombinant Mycobacterium smegmatis expressing an ESAT6-CFP10 fusion protein induces anti-mycobacterial immune responses and protects against Mycobacterium tuberculosis challenge in mice.

@article{Zhang2010RecombinantMS,
  title={Recombinant Mycobacterium smegmatis expressing an ESAT6-CFP10 fusion protein induces anti-mycobacterial immune responses and protects against Mycobacterium tuberculosis challenge in mice.},
  author={Hongyun Zhang and Peike Peng and Shuai Miao and Y Zhao and Feng-feng Mao and L Wang and Y Bai and Z Xu and Shen Wei and Chunwei Shi},
  journal={Scandinavian journal of immunology},
  year={2010},
  volume={72 4},
  pages={349-57}
}
The currently used vaccine against tuberculosis, Bacille Calmette-Guérin (BCG), has variable efficacy, so new vaccine development is crucial. In this study, we evaluated a recombinant vaccine prepared from non-pathogenic Mycobacterium smegmatis (rMS) that expresses a fusion of early secreted antigenic target 6-kDa antigen (ESAT6) and culture filtrate protein 10 (CFP10). C57BL/6 mice were immunized with the rMS expressing the ESAT6-CFP10 fusion protein (rM.S-e6c10) or with BCG. The mice in the… CONTINUE READING
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