Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice.

  title={Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice.},
  author={C. Rappazzo and H. Watkins and C. Guarino and Annie Chau and J. Lopez and M. DeLisa and C. Leifer and G. Whittaker and D. Putnam},
  volume={34 10},
  • C. Rappazzo, H. Watkins, +6 authors D. Putnam
  • Published 2016
  • Biology, Medicine
  • Vaccine
  • Currently approved influenza vaccines predominantly protect through antibodies directed against the highly variable glycoprotein hemagglutinin (HA), necessitating annual redesign and formulation based on epidemiological prediction of predominant circulating strains. More conserved influenza protein sequences, such as the ectodomain of the influenza M2 protein, or M2e, show promise as a component of a universal influenza A vaccine, but require a Th1-biased immune response for activity. Recently… CONTINUE READING
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