Recombinant Lactobacillus plantarum induces immune responses to cancer testis antigen NY-ESO-1 and maturation of dendritic cells.

@article{Mobergslien2015RecombinantLP,
  title={Recombinant Lactobacillus plantarum induces immune responses to cancer testis antigen NY-ESO-1 and maturation of dendritic cells.},
  author={Anne Mobergslien and Vlada Vasovi{\vc} and Geir Mathiesen and Lasse Fredriksen and Phuong Westby and Vincent G H Eijsink and Qian Peng and Mouldy Sioud},
  journal={Human vaccines & immunotherapeutics},
  year={2015},
  volume={11 11},
  pages={2664-73}
}
Given their safe use in humans and inherent adjuvanticity, Lactic Acid Bacteria may offer several advantages over other mucosal delivery strategies for cancer vaccines. The objective of this study is to evaluate the immune responses in mice after oral immunization with Lactobacillus (L) plantarum WCFS1 expressing a cell-wall anchored tumor antigen NY-ESO-1. And to investigate the immunostimulatory potency of this new candidate vaccine on human dendritic cells (DCs). L. plantarum displaying NY… CONTINUE READING