Recombinant Human Elastase Treatment of Cephalic Veins.

  title={Recombinant Human Elastase Treatment of Cephalic Veins.},
  author={Marco D. Wong and Karen Bingham and E. Moss and J. Warn and I. Smirnov and Kimberly S. Bland and B. Starcher and F. N. Franano and S. Burke},
  journal={Cardiovascular pharmacology: open access},
  volume={5 2}
  • Marco D. Wong, Karen Bingham, +6 authors S. Burke
  • Published 2016
  • Medicine
  • Cardiovascular pharmacology: open access
  • BACKGROUND Vessel injury at the time of Arteriovenous Fistula (AVF) creation may lead to neointimal hyperplasia that impairs AVF maturation. Vonapanitase, a recombinant human chymotrypsin-like elastase family member 1, is an investigational drug under development to improve AVF maturation and patency. The current studies were designed to document vonapanitase effects in human cephalic veins that are used in AVF creation. METHODS Human cephalic veins were mounted on a perfusion myograph… CONTINUE READING
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