Recombinant Human Elastase Alters the Compliance of Atherosclerotic Tibial Arteries After Ex Vivo Angioplasty

@article{Burke2016RecombinantHE,
  title={Recombinant Human Elastase Alters the Compliance of Atherosclerotic Tibial Arteries After Ex Vivo Angioplasty},
  author={S. Burke and Karen Bingham and E. Moss and Daniel P. Gottlieb and Marco D. Wong and Kimberly S. Bland and F. N. Franano},
  journal={Journal of Cardiovascular Pharmacology},
  year={2016},
  volume={67},
  pages={305 - 311}
}
  • S. Burke, Karen Bingham, +4 authors F. N. Franano
  • Published 2016
  • Medicine
  • Journal of Cardiovascular Pharmacology
  • Purpose: This study was designed to determine whether vonapanitase (formerly PRT-201), a recombinant human elastase, treatment can fragment the protein elastin in elastic fibers and cause dilation of atherosclerotic human peripheral arteries subjected to ex vivo balloon angioplasty. Materials and Methods: Seven patients undergoing lower limb amputation for peripheral artery disease or who died and donated their bodies to science donated 11 tibial arteries (5 anterior, 6 posterior) for this… CONTINUE READING
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    References

    SHOWING 1-10 OF 20 REFERENCES
    Effects of Recombinant Human Type I Pancreatic Elastase on Human Atherosclerotic Arteries
    • 3
    • PDF
    Quantification of elastic recoil after balloon angioplasty in the iliac arteries.
    • 22
    Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms.
    • 364
    Elastase, collagenase, and the biaxial elastic properties of dog carotid artery.
    • 97
    The architecture of adventitial elastin in the canine infrarenal aorta
    • 32
    Early Recoil After Balloon Angioplasty of Tibial Artery Obstructions in Patients With Critical Limb Ischemia
    • F. Baumann, J. Fust, +5 authors N. Diehm
    • Medicine
    • Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
    • 2014
    • 32
    • PDF
    Balloon angioplasty versus implantation of nitinol stents in the superficial femoral artery.
    • 743