Recombinant GroEL enhances protective antigen-mediated protection against Bacillus anthracis spore challenge

@article{Sinha2012RecombinantGE,
  title={Recombinant GroEL enhances protective antigen-mediated protection against Bacillus anthracis spore challenge},
  author={Kanchan Sinha and Rakesh Bhatnagar},
  journal={Medical Microbiology and Immunology},
  year={2012},
  volume={202},
  pages={153-165}
}
The fatal inhalation infection caused by Bacillus anthracis results from a complex pathogenic cycle involving release of toxins by bacteria that germinate from spores. Currently available vaccines against anthrax consist of protective antigen (PA), one of the anthrax toxin components. However, these PA-based vaccines are only partially protective against spore challenge in mice. This shows that exclusive elicitation of high anti-PA titer does not directly correlate with protection. Here, we… CONTINUE READING
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