Recombinant DNA technology in the treatment of diabetes: insulin analogs.

  title={Recombinant DNA technology in the treatment of diabetes: insulin analogs.},
  author={Zolt{\'a}n Vaj{\'o} and Jodi Fawcett and William C. Duckworth},
  journal={Endocrine reviews},
  volume={22 5},
After more than half a century of treating diabetics with animal insulins, recombinant DNA technologies and advanced protein chemistry made human insulin preparations available in the early 1980s. As the next step, over the last decade, insulin analogs were constructed by changing the structure of the native protein with the goal of improving the therapeutic properties of it, because the pharmacokinetic characteristics of rapid-, intermediate-, and long-acting preparations of human insulin make… CONTINUE READING

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