Recombinant C1 inhibitor in brain ischemic injury.

@article{Gesuete2009RecombinantCI,
  title={Recombinant C1 inhibitor in brain ischemic injury.},
  author={Raffaella Gesuete and Claudio Storini and Alessandro Fantin and Matteo Stravalaci and Elisa Roncati Zanier and Franca Orsini and Helene Vietsch and Maurice L M Mannesse and Bertjan Ziere and Marco Gobbi and Maria-Grazia De Simoni},
  journal={Annals of neurology},
  year={2009},
  volume={66 3},
  pages={332-42}
}
OBJECTIVE C1 inhibitor (C1-INH) is an endogenous inhibitor of complement and kinin systems. We have explored the efficacy and the therapeutic window of the recently available human recombinant (rh) C1-INH on ischemic brain injury and investigated its mechanism of action in comparison with that of plasma-derived (pd) C1-INH. METHODS rhC1-INH was administered intravenously to C57Bl/6 mice undergoing transient or permanent ischemia, and its protective effects were evaluated by measuring infarct… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Microglia and ischemic stroke: a double-edged sword.

International journal of physiology, pathophysiology and pharmacology • 2013
View 4 Excerpts
Highly Influenced

Complement in the brain.

View 7 Excerpts
Highly Influenced

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

BioMed research international • 2014
View 8 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Differential expression of CD45 on canine microglial cells

VM Stein, W Baumgartner, S Schroder
J Vet Med A Physiol Pathol Clin Med • 2007
View 3 Excerpts

inhibitor: biologic activities that are independent of protease inhibition

AE IIIDavis, S Cai, D C1Liu
Immunobiology • 2007

Selective inhibition of plasma kallikrein protects brain from reperfusion injury.

The Journal of pharmacology and experimental therapeutics • 2006
View 3 Excerpts

Similar Papers

Loading similar papers…