Recombinant C1 inhibitor in brain ischemic injury.

  title={Recombinant C1 inhibitor in brain ischemic injury.},
  author={Raffaella Gesuete and Claudio Storini and Alessandro Fantin and Matteo Stravalaci and Elisa Roncati Zanier and Franca Orsini and Helene Vietsch and Maurice L M Mannesse and Bertjan Ziere and Marco Gobbi and Maria-Grazia De Simoni},
  journal={Annals of neurology},
  volume={66 3},
OBJECTIVE C1 inhibitor (C1-INH) is an endogenous inhibitor of complement and kinin systems. We have explored the efficacy and the therapeutic window of the recently available human recombinant (rh) C1-INH on ischemic brain injury and investigated its mechanism of action in comparison with that of plasma-derived (pd) C1-INH. METHODS rhC1-INH was administered intravenously to C57Bl/6 mice undergoing transient or permanent ischemia, and its protective effects were evaluated by measuring infarct… CONTINUE READING


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