Recombinant AAV-mediated gene delivery to the central nervous system.

  title={Recombinant AAV-mediated gene delivery to the central nervous system.},
  author={Liliane Tenenbaum and Abdel Chtarto and Enni Lehtonen and Thierry Velu and Jacques Brotchi and Marc Levivier},
  journal={The journal of gene medicine},
  volume={6 Suppl 1},
Various regions of the brain have been successfully transduced by recombinant adeno-associated virus (rAAV) vectors with no detected toxicity. When using the cytomegalovirus immediate early (CMV) promoter, a gradual decline in the number of transduced cells has been described. In contrast, the use of cellular promoters such as the neuron-specific enolase promoter or hybrid promoters such as the chicken beta-actin/CMV promoter resulted in sustained transgene expression. The cellular tropism of… CONTINUE READING