Recognizing native folds by the arrangement of hydrophobic and polar residues.

@article{Huang1995RecognizingNF,
  title={Recognizing native folds by the arrangement of hydrophobic and polar residues.},
  author={Enoch S. Huang and Subramanian Subbiah and M. Levitt},
  journal={Journal of molecular biology},
  year={1995},
  volume={252 5},
  pages={709-20}
}
Central to the ab initio protein folding problem is the development of an energy function for which the correct native structure has a lower energy than all other conformations. Existing potentials of mean force typically rely extensively on database-derived contact frequencies or knowledge of three-dimensional structural information in order to be successful in the problem of recognizing the native fold for a given sequence from a set of decoy backbone conformations. Is the detailed… CONTINUE READING

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Statistical potentials for fold assessment.

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