Recognizing features that are dissimilar in male and female breast cancer: expression of p21Waf1 and p27Kip1 using an immunohistochemical assay.

@article{Curigliano2002RecognizingFT,
  title={Recognizing features that are dissimilar in male and female breast cancer: expression of p21Waf1 and p27Kip1 using an immunohistochemical assay.},
  author={Giuseppe Curigliano and Marco Colleoni and Giuseppe Renne and Giovanni M Mazzarol and Roberto Gennari and Giulia Peruzzotti and E de Braud and Chris Robertson and Eugenio Maiorano and Paolo Alberto Veronesi and Franco Nol{\'e} and Mario Mandal{\`a} and Gianluigi Ferretti and Giuseppe Viale and Aron Goldhirsch},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2002},
  volume={13 6},
  pages={895-902}
}
BACKGROUND Male breast cancer (MBC) is an uncommon disease, and most of our current knowledge of its biology, natural history and treatment has been extrapolated from data on the disease in women. Information is still needed on the molecular biological properties of male breast tumors and their predictive relevance. Kinase inhibitor proteins (KIPs) p27Kip1 and p21Waf1 negatively regulate cell cycle progression by preventing the passage of cycling cells from G1 to S phase through G1 cyclin… CONTINUE READING
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