Recognizing and treating secondary osteoporosis

@article{WalkerBone2012RecognizingAT,
  title={Recognizing and treating secondary osteoporosis},
  author={Karen Walker-Bone},
  journal={Nature Reviews Rheumatology},
  year={2012},
  volume={8},
  pages={480-492}
}
  • K. Walker-Bone
  • Published 1 August 2012
  • Medicine
  • Nature Reviews Rheumatology
Osteoporosis, through its association with fragility fracture, is a major public health problem, costing an estimated $34.8 billion worldwide per annum. With projected demographic changes, the burden looks set to grow. Therefore, the prevention of osteoporosis, as well as its identification and treatment once established, are becoming increasingly important. Osteoporosis is secondary when a drug, disease or deficiency is the underlying cause. Glucocorticoids, hypogonadism, alcohol abuse and… 
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References

SHOWING 1-10 OF 184 REFERENCES
AGA technical review on osteoporosis in gastrointestinal diseases.
TLDR
Osteoporosis is increasingly recognized as a source of significant disability, an awareness that has prompted clinicians to actively pursue the diagnosis among high-risk patients, and much of the available clinical information regarding osteoporotic screening, outcomes, and therapeutic interventions is derived from the postmenopausal osteoporeosis literature.
Osteoporosis: impact on health and economics
TLDR
Fracture incidence varies between populations, and is set to increase over coming decades as the global population becomes more elderly, particularly marked in the developing world, which is additionally assuming more-westernized lifestyles that predispose to increased fracture risk.
Osteoporosis in men: the value of laboratory testing
TLDR
A relatively modest evaluation of men with osteoporosis found many with undiagnosed secondary causes and multiple unrecognized risk factors, including hypogonadism, vitamin D deficiency, hypercalciuria, subclinical hyperthyroidism, and hyperparathyroidism.
Search for hidden secondary causes in postmenopausal women with osteoporosis
Objective: The prevalence of secondary processes in women with postmenopausal osteoporosis (OP) is not well known. The aim of this study was to analyze the prevalence of conditions contributing to
RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis
TLDR
Denosumab, the only RANKL-targeted therapy currently available, increases bone mineral density and decreases fracture rate in men with prostate cancer and is also associated with delayed time to first skeletal-related event and an increase in bone metastasis-free survival in these men.
Yield of laboratory testing to identify secondary contributors to osteoporosis in otherwise healthy women.
Our purpose in this study was to determine the prevalence of undetected disorders of bone and mineral metabolism in women with osteoporosis and to identify the most useful and cost-efficient
Role of teriparatide in treatment of glucocorticoid-induced osteoporosis
TLDR
Clinical studies have indicated teriparatide is efficacious in the treatment of GIOP to improve bone mineral density values at the lumbar spine and femoral neck, and some evidence also suggests terIParatide may reduce rates of vertebral fractures in GIOP patients.
Osteoporosis and low bone mass in premenopausal and perimenopausal women.
  • C. A. Moreira Kulak, D. Schussheim, E. Shane
  • Medicine
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2000
TLDR
Most young women with osteoporosis or low bone mass had estrogen deficiency or another secondary cause of premature bone loss (or both) and a subset of premenopausal and perimenopausal women, however, had no identifiable cause of bone loss.
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