Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

@article{Jackson2010RecognizingAA,
  title={Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application},
  author={Aimee L Jackson and Peter S. Linsley},
  journal={Nature Reviews Drug Discovery},
  year={2010},
  volume={9},
  pages={57-67}
}
Small interfering RNAs (siRNAs) are widely used to study gene function owing to the ease with which they silence target genes, and there is considerable interest in their potential for therapeutic applications. In a remarkably short time since their discovery, siRNAs have entered human clinical trials in various disease areas. However, rapid acceptance of the use of siRNAs has been accompanied by recognition of several hurdles for the technology, including a lack of specificity. Off-target… 

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