Recognized sequence and conformation in design of linear peptides as a competitive inhibitor for HMG-CoA reductase.


This study is an attempt to develop a simple search method for lead peptide candidates, which include constrained structures in a recognized sequence, using the design of a competitive inhibitor for HMG-CoA reductase (HMGR). A structure-functional analysis of previously synthesized peptides proposes that a competitive inhibitory peptide can be designed by… (More)


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