• DOI:10.1039/c2an15870a
• Corpus ID: 19512108

Recognize three different human telomeric G-quadruplex conformations by quinacrine.

@article{Sun2012RecognizeTD,
  title={Recognize three different human telomeric G-quadruplex conformations by quinacrine.},
  author={Hongxia Sun and Jun-Feng Xiang and Qian Li and Yan Liu and Lin Li and Qian Shang and Guangzhi Xu and Yalin Tang},
  journal={The Analyst},
  year={2012},
  volume={137 4},
  pages={
          862-7
        }
}

• Hongxia Sun, J. Xiang, +5 authors Yalin Tang
• Published 23 January 2012
• Chemistry
• The Analyst

Recognition of different human telomeric G-quadruplex structures has been a very important task for developing anti-cancer drug design. However, it also is a very challenging question since multiple conformational isomers of telomeric G-quadruplexes coexist under some conditions. Here, three different conformations including parallel, antiparallel, and mixed-type telomeric G-quadruplex structures have been well recognized by quinacrine (QNA) through monitoring its absorption, fluorescence, and fluorescence lifetime spectra. The multiple structures of H22 G-quadruplexes under physiological K(+) conditions could also be easily determined to coexist as mixed-type and antiparallel G-quadruplexes. The recognition mechanism based on the different binding affinity and binding sites has been further elucidated by association with the nuclear magnetic resonance (NMR) results.