Recognition of yeast nucleic acids triggers a host-protective type I interferon response.

@article{Biondo2011RecognitionOY,
  title={Recognition of yeast nucleic acids triggers a host-protective type I interferon response.},
  author={Carmelo Biondo and Giacomo Signorino and Alessandro S. Costa and Angelina Midiri and Elisabetta Gerace and Roberta Galbo and Antonella Bellantoni and Antonio Malara and Concetta Beninati and Giuseppe Teti and Giuseppe Mancuso},
  journal={European journal of immunology},
  year={2011},
  volume={41 7},
  pages={1969-79}
}
Although type I interferons (IFN-α/β) have been traditionally associated with antiviral responses, their importance in host defense against bacterial pathogens is being increasingly appreciated. Little is known, however, about the occurrence and functional role of IFN-α/β production in response to pathogenic yeasts. Here, we found that conventional DCs, but not macrophages nor plasmacytoid DCs, mounted IFN-β responses after in vitro stimulation with Candida spp. or Saccharomyces cerevisiae… CONTINUE READING

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Although type I interferons ( IFN-α/β ) have been traditionally associated with antiviral responses , their importance in host defense against bacterial pathogens is being increasingly appreciated .
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