Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements

@article{Malnati1993RecognitionOV,
  title={Recognition of virus-infected cells by natural killer cell clones is controlled by polymorphic target cell elements},
  author={Mauro Severo Malnati and Paolo Lusso and Em{\'i}lio Ciccone and Antonia Moretta and Alessandro Moretta and Eric O Long},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={178},
  pages={961 - 969}
}
Natural killer (NK) cells provide a first line of defense against viral infections. The mechanisms by which NK cells recognize and eliminate infected cells are still largely unknown. To test whether target cell elements contribute to NK cell recognition of virus-infected cells, human NK cells were cloned from two unrelated donors and assayed for their ability to kill normal autologous or allogeneic cells before and after infection by human herpesvirus 6 (HHV-6), a T-lymphotropic herpesvirus. Of… CONTINUE READING

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Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target

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