Recognition of variant Rifin antigens by human antibodies induced during natural Plasmodium falciparum infections.

@article{AbdelLatif2002RecognitionOV,
  title={Recognition of variant Rifin antigens by human antibodies induced during natural Plasmodium falciparum infections.},
  author={Mohamed S. Abdel-Latif and A. Nabil Khattab and Christoph Lindenthal and Peter Gottfried Kremsner and M Klinkert},
  journal={Infection and immunity},
  year={2002},
  volume={70 12},
  pages={7013-21}
}
Antibodies from individuals living in areas where malaria is endemic are known to react with parasite-derived erythrocyte surface proteins. The major immunogenic and clonally variant surface antigen described to date is Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP-1), which is encoded by members of the multicopy var gene family. We report here that rifin proteins (RIF proteins), belonging to the largest known family of variable infected erythrocyte surface-expressed proteins, are… CONTINUE READING