Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.

Abstract

The observation that allogeneic melanoma cells matched for particular HLA class I alleles stimulate T-cells isolated from patients suggests that widely shared antigens exist on these tumors. A transient expression system was developed for screening a melanoma complementary DNA library using the highly transfectable human kidney cell line 293. Using this… (More)

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