Recognition of two epitopes of an antigen present on canine T cells but not on hemopoietic progenitors by four monoclonal antibodies.

@article{Mysliwietz1988RecognitionOT,
  title={Recognition of two epitopes of an antigen present on canine T cells but not on hemopoietic progenitors by four monoclonal antibodies.},
  author={Josef Mysliwietz and Gertrud Hoffmann-Fezer and Stefan Prof Dr Thierfelder and Hans Jochem Kolb and J. Maldacker},
  journal={Transplantation},
  year={1988},
  volume={45 2},
  pages={
          443-8
        }
}
Pairs of murine monoclonal antibodies, which recognize 2 different epitopes on a single antigen are described. These antibodies (MdT-P1, -P2, -Q1, -Q2) defining a canine pan-T cell antigen, were raised against dog thymocytes. In immunoblotting of solubilized and polyacrylamide gradient gel electrophoresis in sodium dodecyl sulphate (SDS-PAGE) fractionated dog thymocytes, they revealed a strong heterogeneous antigen. Competitive inhibition of binding of directly labeled mouse-antidog T… CONTINUE READING
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