Recognition of two classes of oligoproline sequences in profilin- mediated acceleration of actin-based Shigella motility

@article{Zeile1996RecognitionOT,
  title={Recognition of two classes of oligoproline sequences in profilin- mediated acceleration of actin-based Shigella motility},
  author={William L Zeile and Daniel Lee Purich and Frederick Seacrest Southwick},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={133},
  pages={49 - 59}
}
The gram negative rod Shigella flexneri uses it surface protein IcsA to induce host cell actin assembly and to achieve intracellular motility. Yet, the IcsA protein lacks the oligoproline sequences found in ActA, the surface protein required for locomotion of the gram positive rod Listeria monocytogenes. Microinjection of a peptide matching the second ActA oligoproline repeat (FEFPPPPTDE) stops Listeria locomotion (Southwick, F.S., and D.L. Purich. 1994a. Proc. Natl. Acad. Sci. USA. 91:5168… CONTINUE READING

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