Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.

@article{Sims2007RecognitionOT,
  title={Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.},
  author={Robert Joseph Sims and Scott Millhouse and Chi-Fu Chen and Brian A. Lewis and Hediye Erdjument-Bromage and Paul Tempst and James L Manley and Danny F Reinberg},
  journal={Molecular cell},
  year={2007},
  volume={28 4},
  pages={665-76}
}
Trimethylation of histone H3 on lysine 4 (H3K4me3) localizes near the 5' region of genes and is tightly associated with active loci. Several proteins, such as CHD1, BPTF, JMJD2A, and the ING tumor suppressor family, directly recognize this lysine methyl mark. However, how H3K4me3 recognition participates in active transcription remains poorly characterized. Here we identify specific CHD1-interacting proteins via H3K4me3 affinity purification, including numerous factors mediating postinitiation… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes

Nature Structural &Molecular Biology • 2006
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