Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location.

@article{Szendrei1993RecognitionOT,
  title={Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location.},
  author={Gyorgyi I. Szendrei and Virginia M-Y Lee and Laszlo Otvos},
  journal={Journal of neuroscience research},
  year={1993},
  volume={34 2},
  pages={243-9}
}
The major constituent of the paired helical filaments (PHFs) of Alzheimer's disease is the abnormally phosphorylated form of the microtubule-associated protein, tau. Monoclonal antibody (mAb) Tau-1 is used extensively to stain normal human tau, and tau isolated from the brains of Alzheimer's disease patients after dephosphorylation. We used a panel of 6… CONTINUE READING