Recognition of the let‐7g miRNA precursor by human Lin28B

@article{Ali2012RecognitionOT,
  title={Recognition of the let‐7g miRNA precursor by human Lin28B},
  author={P. Shaik Syed Ali and U. Ghoshdastider and J. Hoffmann and B. Brutschy and S. Filipek},
  journal={FEBS Letters},
  year={2012},
  volume={586}
}
  • P. Shaik Syed Ali, U. Ghoshdastider, +2 authors S. Filipek
  • Published 2012
  • Biology, Medicine
  • FEBS Letters
  • Mammalian homologs of lin28: Lin28 and Lin28B block the post‐transcriptional processing of the let‐7 family of miRNAs. We report that in vitro the terminal stem‐loop region of the let‐7g miRNA precursor (pre‐let‐7g) required to bind Lin28B is restricted to 24 nucleotides (nt) including the 3′ GGAG motif. Additionally, full length Lin28B is required for efficient binding to pre‐let‐7g and the stoichiometry of the complex is 1:1. Molecular dynamics (MD) simulations reveal the interactions of the… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28
    • 103
    Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
    • 283
    • Highly Influential
    • PDF
    The Lin28 cold-shock domain remodels pre-let-7 microRNA
    • 67
    • PDF
    Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.
    • 904
    Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28*
    • 328
    • PDF
    Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing.
    • 670
    • PDF
    A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA
    • Y. Huang
    • Biology, Medicine
    • Wiley interdisciplinary reviews. RNA
    • 2012
    • 69
    RAS Is Regulated by the let-7 MicroRNA Family
    • 3,454
    • PDF
    The nuclear RNase III Drosha initiates microRNA processing
    • 4,653
    • PDF