Recognition of the let‐7g miRNA precursor by human Lin28B

  title={Recognition of the let‐7g miRNA precursor by human Lin28B},
  author={P. Shaik Syed Ali and U. Ghoshdastider and J. Hoffmann and B. Brutschy and S. Filipek},
  journal={FEBS Letters},
  • P. Shaik Syed Ali, U. Ghoshdastider, +2 authors S. Filipek
  • Published 2012
  • Biology, Medicine
  • FEBS Letters
  • Mammalian homologs of lin28: Lin28 and Lin28B block the post‐transcriptional processing of the let‐7 family of miRNAs. We report that in vitro the terminal stem‐loop region of the let‐7g miRNA precursor (pre‐let‐7g) required to bind Lin28B is restricted to 24 nucleotides (nt) including the 3′ GGAG motif. Additionally, full length Lin28B is required for efficient binding to pre‐let‐7g and the stoichiometry of the complex is 1:1. Molecular dynamics (MD) simulations reveal the interactions of the… CONTINUE READING
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