Recognition of the let‐7g miRNA precursor by human Lin28B

@article{Ali2012RecognitionOT,
  title={Recognition of the let‐7g miRNA precursor by human Lin28B},
  author={P. Shaik Syed Ali and U. Ghoshdastider and J. Hoffmann and B. Brutschy and S. Filipek},
  journal={FEBS Letters},
  year={2012},
  volume={586}
}
Mammalian homologs of lin28: Lin28 and Lin28B block the post‐transcriptional processing of the let‐7 family of miRNAs. We report that in vitro the terminal stem‐loop region of the let‐7g miRNA precursor (pre‐let‐7g) required to bind Lin28B is restricted to 24 nucleotides (nt) including the 3′ GGAG motif. Additionally, full length Lin28B is required for efficient binding to pre‐let‐7g and the stoichiometry of the complex is 1:1. Molecular dynamics (MD) simulations reveal the interactions of the… Expand
Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors
A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression.
Processing by Drosha and Dicer
A potential regulatory loop between Lin28B:miR-212 in androgen-independent prostate cancer
...
1
2
3
...

References

SHOWING 1-10 OF 26 REFERENCES
Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28
Molecular Basis for Interaction of let-7 MicroRNAs with Lin28
The Lin28 cold-shock domain remodels pre-let-7 microRNA
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.
Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28*
A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA
  • Yingqun Huang
  • Biology, Medicine
  • Wiley interdisciplinary reviews. RNA
  • 2012
RAS Is Regulated by the let-7 MicroRNA Family
The nuclear RNase III Drosha initiates microRNA processing
...
1
2
3
...