Recognition of the amber UAG stop codon by release factor RF1.

  title={Recognition of the amber UAG stop codon by release factor RF1.},
  author={Andrei A Korostelev and Jianyu Zhu and Haruichi Asahara and Harry F. Noller},
  journal={The EMBO journal},
  volume={29 15},
We report the crystal structure of a termination complex containing release factor RF1 bound to the 70S ribosome in response to an amber (UAG) codon at 3.6-A resolution. The amber codon is recognized in the 30S subunit-decoding centre directly by conserved elements of domain 2 of RF1, including T186 of the PVT motif. Together with earlier structures, the mechanisms of recognition of all three stop codons by release factors RF1 and RF2 can now be described. Our structure confirms that the… CONTINUE READING

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Crystal structure of a translation termination complex formed with release factor RF 2

  • A Korostelev, R Bertram, MS Chapman
  • Proc Natl Acad Sci USA
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