Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.

@article{Chen2008RecognitionOT,
  title={Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.},
  author={Zhe Chen and William D. Singer and Shahab M Danesh and Paul C. Sternweis and Stephen R Sprang},
  journal={Structure},
  year={2008},
  volume={16 10},
  pages={1532-43}
}
G12 class heterotrimeric G proteins stimulate RhoA activation by RGS-RhoGEFs. However, p115RhoGEF is a GTPase Activating Protein (GAP) toward Galpha13, whereas PDZRhoGEF is not. We have characterized the interaction between the PDZRhoGEF rgRGS domain (PRG-rgRGS) and the alpha subunit of G13 and have determined crystal structures of their complexes in both the inactive state bound to GDP and the active states bound to GDP*AlF (transition state) and GTPgammaS (Michaelis complex). PRG-rgRGS… CONTINUE READING
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Structure Complexes of the PDZRhoGEF rgRGS Domain

  • E. M. Ross, T. M. Wilkie
  • Annu. Rev. Biochem
  • 2000
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