Recognition of the Helical Cytokine Fold

  title={Recognition of the Helical Cytokine Fold},
  author={Darrell Conklin},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={11 6},
Cytokines are an important class of proteins responsible for intercellular communication. The helical cytokines have a four-helix bundle fold, and they have remained largely intractable for sequence alignment methods due to their high evolutionary divergence. This paper presents a method that is specifically designed to recognize the helical cytokine fold… CONTINUE READING