Recognition of resveratrol by the human estrogen receptor-alpha: a molecular modeling approach to understand its biological actions.

@article{ElMowafy2002RecognitionOR,
  title={Recognition of resveratrol by the human estrogen receptor-alpha: a molecular modeling approach to understand its biological actions.},
  author={Abdalla M. El-Mowafy and Laila A. Abou-zeid and Ivan Ogheneochuko Edafiogho},
  journal={Medical principles and practice : international journal of the Kuwait University, Health Science Centre},
  year={2002},
  volume={11 2},
  pages={86-92}
}
OBJECTIVES Resveratrol (RSVL) is an edible phytoestrogen with multifaceted health benefits that may originate from binding to the estrogen receptors. Despite its structural similarity to the estrogen receptor-alpha (ER alpha) agonist diethylstilbestrol (DES), RSVL showed distinct biological profiles in estrogen-responsive biological systems. The molecular basis of such biological profiles has been undefined. METHODS We considered possible orientations for RSVL in ER alpha binding pocket… CONTINUE READING

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