Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein.

Abstract

The MTH1 protein catalyzes hydrolysis of oxidatively damaged purine nucleotides including 8-hydroxy-dGTP to the monophosphates. The MTH1 protein seems to act as an important defense system against mutagenesis, carcinogenesis, and cell death induced by oxidized purine nucleotides. We previously reported that the functional groups at the 2- and 6-positions of… (More)

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Cite this paper

@article{Kamiya2006RecognitionON, title={Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein.}, author={Hiroyuki Kamiya and Claudio Cadena-Amaro and Laurence Dugu{\'e} and Hiroyuki Yakushiji and Noriaki Minakawa and Akira Matsuda and Sylvie Pochet and Yusaku Nakabeppu and Hideyoshi Harashima}, journal={Journal of biochemistry}, year={2006}, volume={140 6}, pages={843-9} }