Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA.

  title={Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA.},
  author={N Buschta-Hedayat and Tonko Buterin and Martin He\ss and M Missura and Hanspeter Naegeli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 11},
Nondistorting C4' backbone adducts serve as molecular tools to analyze the strategy by which a limited number of human nucleotide excision repair (NER) factors recognize an infinite variety of DNA lesions. We have constructed composite DNA substrates containing a noncomplementary site adjacent to a nondistorting C4' adduct to show that the loss of hydrogen bonding contacts between partner strands is an essential signal for the recruitment of NER enzymes. This specific conformational requirement… CONTINUE READING
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Buschta-Hedayat et al

  • K. Sugasawa, J. M. Ng, +8 authors 223–232. Biochemistry
  • Proc. Natl. Acad. Sci. USA 96
  • 1999
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