Recognition of multiple drugs by a single protein: a trivial solution of an old paradox.

@article{VzquezLaslop2000RecognitionOM,
  title={Recognition of multiple drugs by a single protein: a trivial solution of an old paradox.},
  author={Nora V{\'a}zquez-Laslop and Ekaterina E. Zheleznova and Penelope N. Markham and Richard G Brennan and Alexander A. Neyfakh},
  journal={Biochemical Society transactions},
  year={2000},
  volume={28 4},
  pages={517-20}
}
Multidrug-efflux transporters recognize scores of structurally dissimilar toxic compounds and expel them from cells. The broad chemical specificity of these transporters challenges some of the basic dogmas of biochemistry and remains unexplained. To understand, at least in principle, how a protein can recognize multiple compounds, we analysed the transcriptional regulator of the Bacillus subtilis multidrug transporter Bmr. This regulator, BmrR, binds multiple dissimilar hydrophobic cations and… CONTINUE READING

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