Recognition of microorganisms and activation of the immune response

@article{Medzhitov2007RecognitionOM,
  title={Recognition of microorganisms and activation of the immune response},
  author={Ruslan Medzhitov},
  journal={Nature},
  year={2007},
  volume={449},
  pages={819-826}
}
The mammalian immune system has innate and adaptive components, which cooperate to protect the host against microbial infections. The innate immune system consists of functionally distinct 'modules' that evolved to provide different forms of protection against pathogens. It senses pathogens through pattern-recognition receptors, which trigger the activation of antimicrobial defences and stimulate the adaptive immune response. The adaptive immune system, in turn, activates innate effector… 
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