Recognition of lipid A variants by the TLR4-MD-2 receptor complex

@inproceedings{Maeshima2013RecognitionOL,
  title={Recognition of lipid A variants by the TLR4-MD-2 receptor complex},
  author={Nina Maeshima and R. Castillo Fernandez},
  booktitle={Front. Cell. Inf. Microbio.},
  year={2013}
}
Lipopolysaccharide (LPS) is a component of the outer membrane of almost all Gram-negative bacteria and consists of lipid A, core sugars, and O-antigen. LPS is recognized by Toll-like receptor 4 (TLR4) and MD-2 on host innate immune cells and can signal to activate the transcription factor NFκB, leading to the production of pro-inflammatory cytokines that initiate and shape the adaptive immune response. Most of what is known about how LPS is recognized by the TLR4-MD-2 receptor complex on animal… CONTINUE READING