Recognition of human cytomegalovirus gene products by HCMV-specific cytotoxic T cells.

@article{Boppana1996RecognitionOH,
  title={Recognition of human cytomegalovirus gene products by HCMV-specific cytotoxic T cells.},
  author={Suresh B. Boppana and William J Britt},
  journal={Virology},
  year={1996},
  volume={222 1},
  pages={293-6}
}
The antigen specificity of HCMV-specific cytotoxic T cells (CTL) was investigated in healthy adult seropositive donors by analyzing the frequency of CTL precursors (CTLp) against six different HCMV-encoded proteins. HCMV-specific, CD8+ CTL clones from two donors were also characterized. Thje precursor frequency analysis showed that a major phosphoprotein of HCMV, pp65 (UL83), was the immunodominant CTL target antigen in healthy seropositive adults. The frequency of CTLp specific for different… CONTINUE READING

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