Recognition of host immune activation by Pseudomonas aeruginosa.


It is generally reasoned that lethal infections caused by opportunistic pathogens develop permissively by invading a host that is both physiologically stressed and immunologically compromised. However, an alternative hypothesis might be that opportunistic pathogens actively sense alterations in host immune function and respond by enhancing their virulence phenotype. We demonstrate that interferon-gamma binds to an outer membrane protein in Pseudomonas aeruginosa, OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin. These observations provide details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host.

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@article{Wu2005RecognitionOH, title={Recognition of host immune activation by Pseudomonas aeruginosa.}, author={Licheng R Wu and Oscar Munoz Estrada and Olga Y. Zaborina and Manjeet Bains and Le Shen and Jonathan Emerson Kohler and Nachiket J. Patel and Mark W Musch and Eugene Chang and Y. X. Fu and M. A. Jacobs and Michael I . Nishimura and Robert E. W. Hancock and Jerrold R Turner and John C Alverdy}, journal={Science}, year={2005}, volume={309 5735}, pages={774-7} }