Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.

@article{Wang2008RecognitionOH,
  title={Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d.},
  author={Hua Wang and James Head and Paul Kosma and Helmut Brade and Sven M{\"u}ller-Loennies and Sharmin Sheikh and Barbara L. McDonald and Kelly Smith and Tanya R. Cafarella and Barbara A. Seaton and Erika Crouch},
  journal={Biochemistry},
  year={2008},
  volume={47 2},
  pages={710-20}
}
Lipopolysaccharides (LPS) of Gram-negative bacteria are important mediators of bacterial virulence that can elicit potent endotoxic effects. Surfactant protein D (SP-D) shows specific interactions with LPS, both in vitro and in vivo. These interactions involve binding of the carbohydrate recognition domain (CRD) to LPS oligosaccharides (OS); however, little is known about the mechanisms of LPS recognition. Recombinant neck+CRDs (NCRDs) provide an opportunity to directly correlate binding… CONTINUE READING
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