Recognition of fungal pathogens by toll-like receptors.

  title={Recognition of fungal pathogens by toll-like receptors.},
  author={Mihai G Netea and Gerben Ferwerda and Chantal A. A. van der Graaf and Jos W M van der Meer and Bart Jan Kullberg},
  journal={Current pharmaceutical design},
  volume={12 32},
Toll-like receptors (TLRs) have been identified as a major class of pattern-recognition receptors. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, either alone or in heterodimerization with other TLR or non-TLR receptors, induces signals responsible for the activation of innate immune response. Recent studies have demonstrated a crucial involvement of TLRs in the recognition of fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans… CONTINUE READING
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