Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.

@article{Groft2002RecognitionOE,
  title={Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.},
  author={Caroline M. Groft and Stephen K. Burley},
  journal={Molecular cell},
  year={2002},
  volume={9 6},
  pages={
          1273-83
        }
}
Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP). NSP3 binds to viral mRNA 3' consensus sequences and circularizes mRNA via interactions with eIF4G. Here, we present the X-ray structure of the C-terminal domain of NSP3 (NSP3-C) recognizing a fragment of eIF4GI. Homodimerization of NSP3-C yields a symmetric, elongated… CONTINUE READING
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